Glucocorticoid receptor-IN-2
Modify Date: 2025-08-26 19:32:21
Glucocorticoid receptor-IN-2 structure
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Common Name | Glucocorticoid receptor-IN-2 | ||
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| CAS Number | 2664932-65-2 | Molecular Weight | 512.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H20F4N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Glucocorticoid receptor-IN-2Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1]. |
| Name | Glucocorticoid receptor-IN-2 |
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| Description | Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1]. |
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| Related Catalog | |
| In Vitro | Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1]. |
| References |
| Molecular Formula | C25H20F4N6O2 |
|---|---|
| Molecular Weight | 512.46 |
| InChIKey | ADSMVTGYTNOHRQ-PSLXWICFSA-N |
| SMILES | CC(NC(=O)C(C)(F)F)C(Oc1ccc2c(cnn2-c2ccc3nncn3c2)c1)c1cc(F)cc(F)c1 |