K-Ras ligand-Linker Conjugate 6
Modify Date: 2024-01-03 13:46:52
K-Ras ligand-Linker Conjugate 6 structure
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Common Name | K-Ras ligand-Linker Conjugate 6 | ||
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| CAS Number | 2378261-89-1 | Molecular Weight | 788.98 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C42H60N8O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of K-Ras ligand-Linker Conjugate 6K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
| Name | K-Ras ligand-Linker Conjugate 6 |
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| Description | K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
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| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| Molecular Formula | C42H60N8O7 |
|---|---|
| Molecular Weight | 788.98 |
| Storage condition | -20°C |