JQ1-TCO

Modify Date: 2024-01-27 02:09:02

JQ1-TCO Structure
JQ1-TCO structure
Common Name JQ1-TCO
CAS Number 2087490-43-3 Molecular Weight 609.18
Density N/A Boiling Point N/A
Molecular Formula C31H37ClN6O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JQ1-TCO


JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

 Names

Name JQ1-TCO

 JQ1-TCO Biological Activity

Description JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].
Related Catalog
Target

BRD4

In Vitro JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。
References

[1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270.  

[2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.  

 Chemical & Physical Properties

Molecular Formula C31H37ClN6O3S
Molecular Weight 609.18
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