2087490-43-3

2087490-43-3 structure
2087490-43-3 structure
  • Name: JQ1-TCO
  • Chemical Name: JQ1-TCO
  • CAS Number: 2087490-43-3
  • Molecular Formula: C31H37ClN6O3S
  • Molecular Weight: 609.18
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2023-05-21 17:09:30
  • Modify Date: 2024-01-27 02:09:02
  • JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

Name JQ1-TCO
Description JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].
Related Catalog
Target

BRD4

In Vitro JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。
References

[1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270.  

[2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.  

Molecular Formula C31H37ClN6O3S
Molecular Weight 609.18