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2087490-43-3

2087490-43-3 structure

2087490-43-3 structure

Name: JQ1-TCO
Chemical Name: JQ1-TCO
CAS Number: 2087490-43-3
Molecular Formula: C₃₁H₃₇ClN₆O₃S
Molecular Weight: 609.18
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2023-05-21 17:09:30
Modify Date: 2025-10-05 18:41:06
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

Name	JQ1-TCO

Description	JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4
In Vitro	JQ1-TCO (10 μM; 18 h) 在 HeLa 细胞中不会诱导 BRD4 的显著降解[1]。
References	[1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270. [2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.

Molecular Formula	C₃₁H₃₇ClN₆O₃S
Molecular Weight	609.18

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