JNJ-61432059

Modify Date: 2024-01-10 13:05:03

JNJ-61432059 structure	Common Name	JNJ-61432059
	CAS Number	2035814-50-5	Molecular Weight	443.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₂FN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ-61432059

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

Name	JNJ-61432059

Description	JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	pIC50: 9.7 (AMPAR)[1].
References	[1]. Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272.

Molecular Formula	C₂₅H₂₂FN₅O₂
Molecular Weight	443.47
Storage condition	2-8℃

JNJ-61432059

Use of JNJ-61432059

Names

JNJ-61432059 Biological Activity

Chemical & Physical Properties