JNJ-61432059

Names

[ CAS No. ]:
2035814-50-5

[ Name ]:
JNJ-61432059

Biological Activity

[Description]:

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

pIC50: 9.7 (AMPAR)[1].

[References]

[1]. Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₂FN₅O₂

[ Molecular Weight ]:
443.47

[ Storage condition ]:
2-8℃

Related Compounds

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