4-Thiouridine 5′-triphosphate tetralithium

Modify Date: 2024-03-30 18:11:10

4-Thiouridine 5′-triphosphate tetralithium Structure
4-Thiouridine 5′-triphosphate tetralithium structure
Common Name 4-Thiouridine 5′-triphosphate tetralithium
CAS Number 20188-72-1 Molecular Weight 523.94
Density N/A Boiling Point N/A
Molecular Formula C9H11Li4N2O14P3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-Thiouridine 5′-triphosphate tetralithium


4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].

 Names

Name 4-Thiouridine 5′-triphosphate tetralithium

  Biological Activity

Description 4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].
Related Catalog
Target

P2Y2 Receptor:35 nM (EC50)

P2Y4 Receptor:350 nM (EC50)

References

[1]. Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9.  

[2]. Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31.  

 Chemical & Physical Properties

Molecular Formula C9H11Li4N2O14P3S
Molecular Weight 523.94
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