4-Thiouridine 5′-triphosphate tetralithium

Names

[ CAS No. ]:
20188-72-1

[ Name ]:
4-Thiouridine 5′-triphosphate tetralithium

Biological Activity

[Description]:

4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Research Areas >> Inflammation/Immunology

[Target]

P2Y2 Receptor:35 nM (EC50)

P2Y4 Receptor:350 nM (EC50)


[References]

[1]. Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9.  

[2]. Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H11Li4N2O14P3S

[ Molecular Weight ]:
523.94

Related Compounds