20188-72-1

20188-72-1 structure

Name: 4-Thiouridine 5′-triphosphate tetralithium
Chemical Name: 4-Thiouridine 5′-triphosphate tetralithium
CAS Number: 20188-72-1
Molecular Formula: C₉H₁₁Li₄N₂O₁₄P₃S
Molecular Weight: 523.94
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2023-11-25 16:32:50
Modify Date: 2024-03-30 18:11:10
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].

Name	4-Thiouridine 5′-triphosphate tetralithium

Description	4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology
Target	P2Y2 Receptor:35 nM (EC50) P2Y4 Receptor:350 nM (EC50)
References	[1]. Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9. [2]. Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31.

Molecular Formula	C₉H₁₁Li₄N₂O₁₄P₃S
Molecular Weight	523.94