SDH-IN-2

Modify Date: 2024-01-11 17:47:33

SDH-IN-2 structure	Common Name	SDH-IN-2
	CAS Number	1823354-06-8	Molecular Weight	213.16
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₆F₃NO	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SDH-IN-2

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1].

Name	SDH-IN-2

Description	SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) 完全抑制苹果中 Physalospora piricola 感染，而且即使在 20 μg/mL 低浓度下对所有真菌也显示出 70.9-86.9% 的高抑制率[1]。 SDH-IN-2 抑制 P. oryza 和 F. oxysporum f. sp. niveum 的 EC50 分别为 4.33 和 3.56 μg/mL[1]。 SDH-IN-2 (0-50 μg/mL) 对豆类种子发芽率无影响[1]. SDH-IN-2 (0-100 μg/mL) 对小麦幼苗的生长无显着影响[1]. SDH-IN-2 抑制 SDH 酶活性，IC50 为 0.55 μg/mL[1]。 SDH-IN-2 通过氢键与 SDH 的泛醌结合区较好地结合，发生 π-烷基相互作用和 π-阳离子相互作用[1]。
In Vivo	SDH-IN-2 (化合物 13) (0-200 μg/mL，7 天) 抑制苹果上的 P. piricola 的感染[1]。
References	[1]. Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71(8):3681-3693.

Molecular Formula	C₁₀H₆F₃NO
Molecular Weight	213.16

SDH-IN-2

Use of SDH-IN-2

Names

SDH-IN-2 Biological Activity

Chemical & Physical Properties