MMAF sodium

Modify Date: 2024-01-08 13:35:25

MMAF sodium structure	Common Name	MMAF sodium
	CAS Number	1799706-65-2	Molecular Weight	753.94
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₉H₆₄N₅NaO₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MMAF sodium

MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

Name	MMAF sodium

Description	MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
References	[1]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

Molecular Formula	C₃₉H₆₄N₅NaO₈
Molecular Weight	753.94

MMAF sodium

Use of MMAF sodium

Names

MMAF sodium Biological Activity

Chemical & Physical Properties