1799706-65-2

1799706-65-2 structure

Name: MMAF sodium
Chemical Name: MMAF sodium
CAS Number: 1799706-65-2
Molecular Formula: C₃₉H₆₄N₅NaO₈
Molecular Weight: 753.94
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2019-10-07 08:52:48
Modify Date: 2024-01-08 13:35:25
MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

Name	MMAF sodium

Description	MMAF sodium (Monomethylauristatin F sodium) is an antitubulin agent that inhibit cell division; attenuates its cytotoxic activity compared to MMAE. MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
References	[1]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

Molecular Formula	C₃₉H₆₄N₅NaO₈
Molecular Weight	753.94