Scyllatoxin

Modify Date: 2024-01-11 18:08:26

Scyllatoxin structure	Common Name	Scyllatoxin
	CAS Number	142948-19-4	Molecular Weight	3429.18000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄₂H₂₄₃N₄₅O₃₉S₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Scyllatoxin

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].

Name	leiurotoxin i
Synonym	More Synonyms

Description	Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	For scyllatoxin, the Arg6 and Arg13 are essential for binding to the Ca2+-activated K+ channel protein and for the functional effect of the toxin[1]. For scyllatoxin, His31 is important for the binding activity of the toxin and for the induction of contractions on taenia coli[1].
In Vivo	Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats[2].
References	[1]. Auguste P, et al. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31(3):648-54. [2]. Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56(2):263-9.

Molecular Formula	C₁₄₂H₂₄₃N₄₅O₃₉S₇
Molecular Weight	3429.18000
Exact Mass	3426.65000
PSA	1631.99000
LogP	4.11960

Scyllatoxin,LeTx I

Leiurotoxin I Scyllatoxin,LeTx I

ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2

LETX I SCORPION TOXIN

LETX I

H-Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2

SCYLLATOXIN

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Scyllatoxin

Use of Scyllatoxin

Names

Scyllatoxin Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.