Scyllatoxin

Names

[ CAS No. ]:
142948-19-4

[ Name ]:
Scyllatoxin

[Synonym ]:
Scyllatoxin,LeTx I
Leiurotoxin I Scyllatoxin,LeTx I
ALA-PHE-CYS-ASN-LEU-ARG-MET-CYS-GLN-LEU-SER-CYS-ARG-SER-LEU-GLY-LEU-LEU-GLY-LYS-CYS-ILE-GLY-ASP-LYS-CYS-GLU-CYS-VAL-LYS-HIS-NH2
LETX I SCORPION TOXIN
LETX I
H-Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2
SCYLLATOXIN

Biological Activity

[Description]:

Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

For scyllatoxin, the Arg6 and Arg13 are essential for binding to the Ca2+-activated K+ channel protein and for the functional effect of the toxin[1]. For scyllatoxin, His31 is important for the binding activity of the toxin and for the induction of contractions on taenia coli[1].

[In Vivo]

Scyllatoxin (2 μM) increases basal Epi release, the nerve stimulation-induced Epi release and the exogenous acetylcholine (Ach)-induced catecholamine release by microdialysis technique to the left adrenal medulla of anesthetized adult male Wistar rats[2].

[References]

[1]. Auguste P, et al. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 1992 Jan 28;31(3):648-54.

[2]. Akiyama T, et al. Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla. Neurochem Int. 2010 Jan;56(2):263-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C142H243N45O39S7

[ Molecular Weight ]:
3429.18000

[ Exact Mass ]:
3426.65000

[ PSA ]:
1631.99000

[ LogP ]:
4.11960

Related Compounds

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