AChE/BChE/BACE-1-IN-1
Modify Date: 2024-01-09 20:31:00
AChE/BChE/BACE-1-IN-1 structure
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Common Name | AChE/BChE/BACE-1-IN-1 | ||
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| CAS Number | 1321361-13-0 | Molecular Weight | 350.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21F3N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE/BChE/BACE-1-IN-1AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1]. |
| Name | AChE/BChE/BACE-1-IN-1 |
|---|
| Description | AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1]. |
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| Related Catalog | |
| Target |
IC50: 0.058 μM (hAChE), 0.082 μM (hBChE), 0.115 μM (hBACE-1)[1] |
| In Vivo | AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1]. |
| References |
| Molecular Formula | C19H21F3N2O |
|---|---|
| Molecular Weight | 350.38 |