Soluble epoxide hydrolase inhibitor

Modify Date: 2024-01-04 20:06:10

Soluble epoxide hydrolase inhibitor structure	Common Name	Soluble epoxide hydrolase inhibitor
	CAS Number	1241826-88-9	Molecular Weight	441.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₂F₅N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Soluble epoxide hydrolase inhibitor

Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.

Name	Soluble epoxide hydrolase inhibitor

Description	Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	pIC50: 8.4 (h-sEH)[1]
In Vitro	Soluble epoxide hydrolase inhibitor (Example 57) is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase with pIC50 of 8.4[1].
Kinase Assay	The sEH inhibitory properties of test compounds (including Soluble epoxide hydrolase inhibitor) are determined using a black 384-well-plate format under the following reaction conditions: 20 mM Tris pH 7.0, 0.1 mM EDTA, 0.1 mg/mL BSA, 5 μM PHOME (substrate), 2 nM sEH enzyme, 1% DMSO (from test compound). Reaction product is determined quantitatively by fluorescence intensity using a Fluorescence plate reader with an excitation wavelength at 330 nm and emission at 465 nm[1].
References	[1]. 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS. WO 2010096722 A1

Molecular Formula	C₁₈H₁₂F₅N₅O₃
Molecular Weight	441.31