402939-18-8

402939-18-8 structure

Name: 1-Cyclohexyl-3-dodecyl urea
Chemical Name: 1-cyclohexyl-3-dodecylurea
CAS Number: 402939-18-8
Molecular Formula: C₁₉H₃₈N₂O
Molecular Weight: 310.51800
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-03-28 22:06:49
Modify Date: 2025-08-26 19:35:18
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].

Name	1-cyclohexyl-3-dodecylurea
Synonyms	Urea,N-cyclohexyl-N'-dodecyl Soluble Epoxide Hydrolase Inhibitor,NCND

Description	1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: soluble epoxide hydrolase (sEH)[1]
In Vivo	1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3mg/day Administration: Intraperitoneal injection; 4 days Result: Had antihypertensive properties.
References	[1]. Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002 Feb;39(2 Pt 2):690-4.