2'-Deoxy-2'-fluoroguanosine

Modify Date: 2026-07-07 09:25:08

2'-Deoxy-2'-fluoroguanosine structure	Common Name	2'-Deoxy-2'-fluoroguanosine
	CAS Number	103884-98-6	Molecular Weight	285.23
	Density	2.2±0.1 g/cm3	Boiling Point	726.1ºC
	Molecular Formula	C₁₀H₁₂FN₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	392.9ºC

Use of 2'-Deoxy-2'-fluoroguanosine

2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	2.2±0.1 g/cm3
Boiling Point	726.1ºC
Molecular Formula	C₁₀H₁₂FN₅O₄
Molecular Weight	285.23
Flash Point	392.9ºC
Exact Mass	285.087341
PSA	139.28000
LogP	-0.53
Vapour Pressure	3.94E-22mmHg at 25°C
Index of Refraction	1.876
InChIKey	UXUZARPLRQRNNX-UHFFFAOYSA-N
SMILES	Nc1nc2c(ncn2C2OC(CO)C(O)C2F)c(=O)[nH]1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0789000

CHEMICAL NAME :: 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro-

CAS REGISTRY NUMBER :: 103884-98-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-F-N5-O4

MOLECULAR WEIGHT :: 285.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:118373-61-8 2-Amino-6-chlor... CAS#:5451-40-1 2,6-Dichloropurine CAS#:56632-81-6 1,3-di-O-acetyl... CAS#:103884-99-7 9H-Purine, 9-(3...
CAS#:103885-01-4 2,6-diazido-9-(... CAS#:109303-94-8 9-(3-O-acetyl-5... CAS#:97614-44-3 2-Deoxy-2-fluor... CAS#:72101-44-1 6-Chloro-9,N-bi...
CAS#:103885-02-5 9-(3-O-acetyl-5...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Compound was tested for its ability to inhibit the incorporation of [3H]dThd into DNA...
Source: ChEMBL
Target: L1210
External Id: CHEMBL701050

Name: Cytotoxicity was evaluated by measuring the inhibition of HSV replication in vero cel...
Source: ChEMBL
Target: Vero
External Id: CHEMBL820065

Name: Concentration required to inhibit HSV-1 strain KOS cytopathic effect by 50% was measu...
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL694043

Name: Inhibition of DNA synthesis in L1210 cells by the compound was determined the reduced...
Source: ChEMBL
Target: L1210
External Id: CHEMBL704582

Name: Inhibition of DNA synthesis in L1210 cells by the compound was determined the reduced...
Source: ChEMBL
Target: L1210
External Id: CHEMBL704581

Name: Inhibition of protein synthesis in L1210 cells by the compound was determined the red...
Source: ChEMBL
Target: L1210
External Id: CHEMBL704583

Name: Inhibition of RNA synthesis in L1210 cells by the compound was determined the reduced...
Source: ChEMBL
Target: L1210
External Id: CHEMBL873013

Name: Concentration required to inhibit HSV-2 strain 186 cytopathic effect by 50% was measu...
Source: ChEMBL
Target: Human alphaherpesvirus 2
External Id: CHEMBL689430

Total 8, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one

2'-Deoxy-2'-fluoroguanosine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: CAS number of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is 103884-98-6.

Q: What English synonyms does 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one have?

A: English synonyms of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one: 2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one, 2'-Deoxy-2'-fluoroguanosine.

Q: What is the English name of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: The English name of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one.

Q: What is the SMILES notation of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: SMILES notation of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is Nc1nc2c(ncn2C2OC(CO)C(O)C2F)c(=O)[nH]1.

Q: What is the boiling point of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: Boiling point of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is 726.1ºC.

Q: What is the InChIKey of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: InChIKey of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is UXUZARPLRQRNNX-UHFFFAOYSA-N.

Q: What is the molecular weight of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: Molecular weight of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is 285.23.

Q: What is the polar surface area (PSA) of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: Polar surface area (PSA) of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is 139.28000.

Q: What is the molecular formula of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: Molecular formula of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is C10H12FN5O4.

Q: What is the LogP of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one?

A: LogP of 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one is -0.53.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2'-Deoxy-2'-fluoroguanosine
Price: Check
Purity: 99.42%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-(2-DEOXY-2-FLUOROARABINOFURANOSYL)GUANINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥7722/100mg

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2'-Deoxy-2'-fluoroguanosine

Use of 2'-Deoxy-2'-fluoroguanosine

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