Tamoxifen structure
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Common Name | Tamoxifen | ||
|---|---|---|---|---|
| CAS Number | 10540-29-1 | Molecular Weight | 371.515 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 482.3±33.0 °C at 760 mmHg | |
| Molecular Formula | C26H29NO | Melting Point | 97-98ºC | |
| MSDS | Chinese USA | Flash Point | 140.0±27.7 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of TamoxifenTamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | tamoxifen |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. |
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| Related Catalog | |
| Target |
Estrogen receptor[1] |
| In Vitro | Tamoxifen shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2]. |
| In Vivo | The Tamoxifen-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/- mice are given a daily Iintraperitoneal injection of Tamoxifen at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3]. |
| Animal Admin | Mice[3] Seven-week old TmcsMed1-/- mice and the wild-type littermates are then administered Tamoxifen intraperitoneally at a daily dose of 65 mg/kg body weight for 5 days and then killed at selected intervals after initiation of Tamoxifen treatment. For each experiment 3 to 5 mice for control and csMed1-/- are used. To obtain survival curve 41 csMed1-/- and 41 csMed1fl/fl mice are used. Thirteen TmcsMed-/- mice and the same number of littermates are used for the survival curve experiments using Tamoxifen inducible model. The specific criteria for animal euthanasia included absence of food or water intake, slow or no mobility, weak or absence of heart beat, absence of palpitation of the chest as well as absence of respiratory movement. Mice are euthanized by intraperitoneal pentobarbital injection at the dose of 150mg/kg body weight to minimize suffering. |
| References |
[1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 482.3±33.0 °C at 760 mmHg |
| Melting Point | 97-98ºC |
| Molecular Formula | C26H29NO |
| Molecular Weight | 371.515 |
| Flash Point | 140.0±27.7 °C |
| Exact Mass | 371.224915 |
| PSA | 12.47000 |
| LogP | 7.88 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.582 |
| InChIKey | NKANXQFJJICGDU-QPLCGJKRSA-N |
| SMILES | CCC(=C(c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H350-H360-H362 |
| Precautionary Statements | P201-P263-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R45;R60;R61;R64 |
| Safety Phrases | S53-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | KR5919600 |
| HS Code | 2922199090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
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| DownStream 7 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922199090 |
|---|---|
| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.
Biochim. Biophys. Acta 1839(11) , 1273-82, (2014) GATA4 is expressed in the proximal 85% of small intestine where it promotes a proximal intestinal ('jejunal') identity while repressing a distal intestinal ('ileal') identity, but its molecular mechan... |
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TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer.
Oncogene 34(1) , 27-38, (2015) Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2... |
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Potential therapeutic benefit of combining gefitinib and tamoxifen for treating advanced lung adenocarcinoma.
Biomed Res. Int. 2015 , 642041, (2015) Epidermal growth factor receptor (EGFR) mutations are known as oncogene driver mutations and with EGFR mutations exhibit good response to the EGFR tyrosine kinase inhibitor Gefitinib. Some studies hav... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| [3H]-Tamoxifen |
| EINECS 234-118-0 |
| trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine |
| Valodex |
| 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine |
| [14C]-Tamoxifen |
| (Z)-1-{4-[2-(dimethylamino)ethoxy]-phenyl}-1,2-diphenyl-1-butene |
| Tamoxen |
| 2-{4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine |
| cis-Tamoxifen |
| Tamizam |
| Istubal |
| Oncomox |
| Soltamox |
| Crisafeno |
| Citofen |
| Tamoxifen |
| Diemon |
| MFCD00010454 |
| Tamoxifene |
| 2YR&UYR&R DO2N1&1 &&Z Form |
| (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine |
| [Z]-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine |
| 1-p-b-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene |
| 2-{4-[(1Z)-1,2-Diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine |
| Zemide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of tamoxifen? |
| A: Boiling point of tamoxifen is 482.3±33.0 °C at 760 mmHg. |
| Q: What is the CAS number of tamoxifen? |
| A: CAS number of tamoxifen is 10540-29-1. |
| Q: What is the molecular formula of tamoxifen? |
| A: Molecular formula of tamoxifen is C26H29NO. |
| Q: What is the SMILES notation of tamoxifen? |
| A: SMILES notation of tamoxifen is CCC(=C(c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1. |
| Q: What are the uses of tamoxifen? |
| A: Main uses of tamoxifen: Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. |
| Q: What is the LogP of tamoxifen? |
| A: LogP of tamoxifen is 7.88. |
| Q: What is the melting point of tamoxifen? |
| A: Melting point of tamoxifen is 97-98ºC. |
| Q: What are the upstream materials of tamoxifen? |
| A: Related upstream materials(CAS) of tamoxifen: 93790-54-6;604010-60-8;591-50-4;622-76-4;194594-60-0;13002-65-8;113619-15-1;918793-63-2. |
| Q: What is the safety information for tamoxifen? |
| A: Safety information for tamoxifen: S53-S45. |
| Q: What is the molecular weight of tamoxifen? |
| A: Molecular weight of tamoxifen is 371.515. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |