Rufinamide
Rufinamide structure
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Common Name | Rufinamide | ||
|---|---|---|---|---|
| CAS Number | 106308-44-5 | Molecular Weight | 238.193 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 473.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C10H8F2N4O | Melting Point | 232-234?C | |
| MSDS | Chinese USA | Flash Point | 240.4±31.5 °C | |
Use of RufinamideRufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2 |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Rufinamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).IC50 Value:Target: in vitro:in vivo: Rufinamide and amitriptyline alleviated injury-induced mechanical allodynia for 4 h (maximal effect: 0.10 ± 0.03 g (mean ± SD) to 1.99 ± 0.26 g for rufinamide and 0.25 ± 0.22 g to 1.92 ± 0.85 g for amitriptyline) in mice [1]. Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and was active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg) [2]. Intraperitoneal rufinamide suppressed pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively).Clinical trial: Exploratory Study to Evaluate the Effect of SYN-111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD). Phase 2 |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 473.8±55.0 °C at 760 mmHg |
| Melting Point | 232-234?C |
| Molecular Formula | C10H8F2N4O |
| Molecular Weight | 238.193 |
| Flash Point | 240.4±31.5 °C |
| Exact Mass | 238.066620 |
| PSA | 73.80000 |
| LogP | 0.05 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.635 |
| InChIKey | POGQSBRIGCQNEG-UHFFFAOYSA-N |
| SMILES | NC(=O)c1cn(Cc2c(F)cccc2F)nn1 |
| Storage condition | −20°C |
| Water Solubility | DMSO: soluble9mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | F,T |
|---|---|
| Risk Phrases | 11-23/24/25-39/23/24/25-48-41-38-28 |
| Safety Phrases | 7-16-36/37-45-36/37/39-28-26-24/25 |
| RIDADR | UN 1648 3 / PGII |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Dose-dependent pharmacokinetics and brain penetration of rufinamide following intravenous and oral administration to rats.
Eur. J. Pharm. Sci. 68 , 106-13, (2015) Rufinamide is a third-generation antiepileptic drug, approved recently as an orphan drug for the treatment of Lennox-Gastaut syndrome. Although extensive research was conducted, its pharmacokinetics i... |
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Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of basic drugs and metabolites.
Biomed. Chromatogr. 29 , 935-52, (2015) An automated multi-analyte screening method for the identification and quantification of 92 drugs and metabolites based on on-line solid-phase extraction-high-performance liquid chromatography-diode a... |
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Rufinamide for the treatment of Lennox-Gastaut syndrome.
Expert Opin. Pharmacother. 12(5) , 801-6, (2011) Lennox-Gastaut syndrome (LGS) is a severe treatment-resistant childhood-onset epilepsy. This review examines the role of the new drug rufinamide for the treatment of LGS.MEDLINE and Google Scholar sea... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
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Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide |
| 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| Rufinamide |
| 1-((2,6-Difluorophenyl)methyl)-1H-1,2,3-triazole-4-carboxamide |
| Banzel |
| Inovelon |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does Rufinamide have? |
| A: English synonyms of Rufinamide: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide, 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide, Rufinamide, 1-((2,6-Difluorophenyl)methyl)-1H-1,2,3-triazole-4-carboxamide, Banzel, Inovelon. |
| Q: What is the polar surface area (PSA) of Rufinamide? |
| A: Polar surface area (PSA) of Rufinamide is 73.80000. |
| Q: What is the melting point of Rufinamide? |
| A: Melting point of Rufinamide is 232-234?C. |
| Q: How is the water solubility of Rufinamide? |
| A: Water solubility of Rufinamide: DMSO: soluble9mg/mL. |
| Q: What is the LogP of Rufinamide? |
| A: LogP of Rufinamide is 0.05. |
| Q: What is the boiling point of Rufinamide? |
| A: Boiling point of Rufinamide is 473.8±55.0 °C at 760 mmHg. |
| Q: What is the molecular weight of Rufinamide? |
| A: Molecular weight of Rufinamide is 238.193. |
| Q: What is the molecular formula of Rufinamide? |
| A: Molecular formula of Rufinamide is C10H8F2N4O. |
| Q: What are the storage conditions for Rufinamide? |
| A: Storage conditions for Rufinamide: −20°C. |
| Q: What is the safety information for Rufinamide? |
| A: Safety information for Rufinamide: 7-16-36/37-45-36/37/39-28-26-24/25. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |