Berberine
Berberine structure
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Common Name | Berberine | ||
|---|---|---|---|---|
| CAS Number | 2086-83-1 | Molecular Weight | 336.361 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18NO4+ | Melting Point | 204-206ºC (dec.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of BerberineBerberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1]. |
Summary: Berberine, also known as Huanglianxian, has a molecular formula of C20H18NO4+ and a molecular weight of 336.361. It is a yellow crystalline substance with a melting point of 204-206ºC. For storage, it should be kept in low temperature, well-ventilated, and dry conditions, limited in quantity to prevent excessive exposure, and precautions should be taken against skin absorption. It is primarily used to treat intestinal infections, showing antimicrobial activity against streptococcus hemolyticus, staphylococcus aureus, and other bacteria, with some inhibitory effects on tubercle bacilli and plague bacilli. It is widely used to treat gastroenteritis, bacillary dysentery, and has certain therapeutic effects on pulmonary tuberculosis, scarlet fever, acute tonsillitis, and respiratory infections. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | berberine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 204-206ºC (dec.) |
|---|---|
| Molecular Formula | C20H18NO4+ |
| Molecular Weight | 336.361 |
| Exact Mass | 336.123047 |
| PSA | 40.80000 |
| LogP | -0.99 |
| InChIKey | YBHILYKTIRIUTE-UHFFFAOYSA-N |
| SMILES | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~%
Berberine CAS#:2086-83-1 |
| Literature: Natural Product Research, , vol. 28, # 7 p. 413 - 419 |
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~14%
Berberine CAS#:2086-83-1
Learn More
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| Literature: Helvetica Chimica Acta, , vol. 85, # 4 p. 1069 - 1078 |
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~96%
Berberine CAS#:2086-83-1 |
| Literature: Hanaoka, Miyoji; Ashimori, Atsuyuki; Yasuda, Shingo Heterocycles, 1984 , vol. 22, # 10 p. 2263 - 2264 |
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Berberine CAS#:2086-83-1 |
| Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723 |
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Berberine CAS#:2086-83-1 |
| Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723 |
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~%
Berberine CAS#:2086-83-1 |
| Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723 |
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Berberine CAS#:2086-83-1 |
| Literature: Heterocycles, , vol. 22, # 10 p. 2263 - 2264 |
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~%
Berberine CAS#:2086-83-1 |
| Literature: Heterocycles, , vol. 22, # 10 p. 2263 - 2264 |
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~%
Berberine CAS#:2086-83-1 |
| Literature: Natural Product Research, , vol. 28, # 7 p. 413 - 419 |
![6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8,13,13a-tetrahydro-9,10-dimethoxy structure](https://image.chemsrc.com/caspic/313/29074-38-2.png)
![3-[3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl]-4,5-dimethoxy-1(3H)-isobenzofuranone structure](https://image.chemsrc.com/caspic/207/64939-64-6.png)
![(4bS,14bR,15S)-3,4-dimethoxy-4b,8,9,15-tetrahydro-6H-[1,3]dioxolo[4,5-g]indeno[2',1':4,5]oxazolo[4,3-a]isoquinolin-15-ol structure](https://image.chemsrc.com/caspic/145/94272-85-2.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 8 | |
CAS#:483-15-8
CAS#:3486-66-6![1,3-Dioxolo[4,5-g]isoquinolin-5(6H)-one,7,8-dihydro structure](https://image.chemsrc.com/caspic/031/21796-14-5.png)
CAS#:21796-14-5![Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-13-hydroxy-8,9,10-trimethoxy-, inner salt (9CI) structure](https://image.chemsrc.com/caspic/008/61138-60-1.png)
CAS#:61138-60-1
CAS#:62595-72-6
CAS#:66408-27-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Berberine |
| EINECS 211-195-9 |
| 5,6-Dihydro-9,10-dimethoxybenzo[g]1,3-benzodioxolo[5,6-a]quinolizinium |
| 9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium |
| 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium |
| Berberin |
| 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium |
| MFCD00011939 |
| 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium |
| 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of berberine? |
| A: Main uses of berberine: Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1]. |
| Q: What is the molecular formula of berberine? |
| A: Molecular formula of berberine is C20H18NO4+. |
| Q: What are the upstream materials of berberine? |
| A: Related upstream materials(CAS) of berberine: 29074-38-2;633-65-8;113975-46-5;84229-90-3;485-91-6. |
| Q: What is the melting point of berberine? |
| A: Melting point of berberine is 204-206ºC (dec.). |
| Q: What is the safety information for berberine? |
| A: Safety information for berberine: S24/25. |
| Q: What are the downstream products of berberine? |
| A: Related downstream products(CAS) of berberine: 483-15-8;3486-66-6;21796-14-5;61138-60-1;62595-72-6;549-21-3;64939-64-6;66408-27-3. |
| Q: What is the LogP of berberine? |
| A: LogP of berberine is -0.99. |
| Q: What is the molecular weight of berberine? |
| A: Molecular weight of berberine is 336.361. |
| Q: What is the SMILES notation of berberine? |
| A: SMILES notation of berberine is COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2. |
| Q: What is the CAS number of berberine? |
| A: CAS number of berberine is 2086-83-1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |