Daphnetin
Daphnetin structure
|
Common Name | Daphnetin | ||
|---|---|---|---|---|
| CAS Number | 486-35-1 | Molecular Weight | 178.14 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 430.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C9H6O4 | Melting Point | 265-268°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 184.5±22.2 °C | |
Use of DaphnetinDaphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 7,8-dihydroxycoumarin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3]. |
|---|---|
| Related Catalog | |
| Target |
EGFR:7.67 μM (IC50) PKA:9.33 μM (IC50) PKC:25.01 μM (IC50) |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 430.4±45.0 °C at 760 mmHg |
| Melting Point | 265-268°C (dec.) |
| Molecular Formula | C9H6O4 |
| Molecular Weight | 178.14 |
| Flash Point | 184.5±22.2 °C |
| Exact Mass | 178.026611 |
| PSA | 70.67000 |
| LogP | 0.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.689 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | GN6382600 |
| HS Code | 2942000000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 6 | |
CAS#:617-48-1
CAS#:87-66-1
CAS#:104819-86-5
CAS#:471-25-0
CAS#:2445-80-9
CAS#:19492-03-6
CAS#:76474-93-6
CAS#:108-24-7
CAS#:110-16-7
CAS#:2067-86-9
CAS#:21784-71-4
CAS#:483-92-1
CAS#:485-90-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
|
|
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened... |
|
|
Thousands of chemical starting points for antimalarial lead identification.
Nature 465 , 305-10, (2010) Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 19... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Daphnetin |
| 7,8-Dihydroxychromen-2-one |
| 7,8-Dihydroxycoumarin |
| 7,8-dihydroxy-coumarin |
| EINECS 207-632-8 |
| 7,8-Dihydroxy-2H-chromen-2-one |
| 7,8-Dihydroxy-2H-1-benzopyran-2-one |
| MFCD00016977 |
| TCMDC-125839 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of 7,8-dihydroxycoumarin? |
| A: Related upstream materials(CAS) of 7,8-dihydroxycoumarin: 617-48-1;87-66-1;104819-86-5;471-25-0;2445-80-9;19492-03-6;76474-93-6;108-24-7;110-16-7;2067-86-9. |
| Q: What is the polar surface area (PSA) of 7,8-dihydroxycoumarin? |
| A: Polar surface area (PSA) of 7,8-dihydroxycoumarin is 70.67000. |
| Q: What is the English name of 7,8-dihydroxycoumarin? |
| A: The English name of 7,8-dihydroxycoumarin is 7,8-dihydroxycoumarin. |
| Q: What is the molecular formula of 7,8-dihydroxycoumarin? |
| A: Molecular formula of 7,8-dihydroxycoumarin is C9H6O4. |
| Q: What is the melting point of 7,8-dihydroxycoumarin? |
| A: Melting point of 7,8-dihydroxycoumarin is 265-268°C (dec.). |
| Q: What are the downstream products of 7,8-dihydroxycoumarin? |
| A: Related downstream products(CAS) of 7,8-dihydroxycoumarin: 19492-03-6;2445-80-9;21784-71-4;76474-93-6;483-92-1;485-90-5. |
| Q: What is the CAS number of 7,8-dihydroxycoumarin? |
| A: CAS number of 7,8-dihydroxycoumarin is 486-35-1. |
| Q: What English synonyms does 7,8-dihydroxycoumarin have? |
| A: English synonyms of 7,8-dihydroxycoumarin: Daphnetin, 7,8-Dihydroxychromen-2-one, 7,8-Dihydroxycoumarin, 7,8-dihydroxy-coumarin, EINECS 207-632-8, 7,8-Dihydroxy-2H-chromen-2-one, 7,8-Dihydroxy-2H-1-benzopyran-2-one, MFCD00016977, TCMDC-125839. |
| Q: What is the molecular weight of 7,8-dihydroxycoumarin? |
| A: Molecular weight of 7,8-dihydroxycoumarin is 178.14. |
| Q: What is the boiling point of 7,8-dihydroxycoumarin? |
| A: Boiling point of 7,8-dihydroxycoumarin is 430.4±45.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |