wedelolactone
wedelolactone structure
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Common Name | wedelolactone | ||
|---|---|---|---|---|
| CAS Number | 524-12-9 | Molecular Weight | 314.246 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 498.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H10O7 | Melting Point | 315 °C | |
| MSDS | Chinese USA | Flash Point | 255.2±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of wedelolactoneWedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | wedelolactone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-11 5-lipoxygenase:2.5 μM (IC50) Apoptosis |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.4±45.0 °C at 760 mmHg |
| Melting Point | 315 °C |
| Molecular Formula | C16H10O7 |
| Molecular Weight | 314.246 |
| Flash Point | 255.2±28.7 °C |
| Exact Mass | 314.042664 |
| PSA | 113.27000 |
| LogP | 2.75 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.759 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 14 mg/mL, soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H317 |
| Precautionary Statements | P280-P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R43 |
| Safety Phrases | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
|---|---|
| DownStream 0 | |
CAS#:627489-05-8![1-hydroxy-3-methoxy-8,9-diisopropyloxy-benzo[4,5]furo[3,2-c]chromen-6-one Structure](https://image.chemsrc.com/caspic/328/1023744-97-9.png)
CAS#:1023744-97-9
CAS#:5447-02-9
CAS#:27688-86-4
CAS#:27688-85-3
CAS#:139-85-5
CAS#:627489-10-5
CAS#:627489-15-0
CAS#:344303-12-4This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils.
J. Infect. Dis. 210(4) , 656-66, (2014) Neutrophils are rapidly recruited to the site of Leishmania infection and play an active role in capturing and killing parasites. They are the main source of leukotriene B4 (LTB4), a potent proinflamm... |
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CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.
Cell. Microbiol. 10(11) , 2247-56, (2008) Bacteraemic pneumonia is a common cause of sepsis in critically ill patients today and is characterized by dysregulation of inflammation. The genetic factors predisposing to bacteraemic pneumonia are ... |
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Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice.
Eur. J. Med. Chem. 56 , 361-7, (2012) The anticancer properties of demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-i... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of Hepatitis C virus NS5B polymerase
Source: ChEMBL
Target: N/A
External Id: CHEMBL5257818
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Name: Potency index, ratio of coumestrol IC50 to compound IC50 for 5-lipoxygenase in pig le...
Source: ChEMBL
Target: Arachidonate 5-lipoxygenase
External Id: CHEMBL3874972
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Name: Delta TM value showing the stabilisation of CAMK2G produced by compound binding
Source: ChEMBL
Target: Calcium/calmodulin-dependent protein kinase type II subunit gamma
External Id: CHEMBL3430795
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Name: Delta TM value showing the stabilisation of CAMK4 produced by compound binding
Source: ChEMBL
Target: Calcium/calmodulin-dependent protein kinase type IV
External Id: CHEMBL3430796
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Name: Cytotoxicity against human MDA-MB-231 cells at 25 to 100 uM after 24 hrs by MTT assay
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL2089625
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Name: Delta TM value showing the stabilisation of CAMK2B produced by compound binding
Source: ChEMBL
Target: Calcium/calmodulin-dependent protein kinase type II subunit beta
External Id: CHEMBL3430793
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Name: Delta TM value showing the stabilisation of CAMK2D produced by compound binding
Source: ChEMBL
Target: Calcium/calmodulin-dependent protein kinase type II subunit delta
External Id: CHEMBL3430794
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Name: Delta TM value showing the stabilisation of CDK6 produced by compound binding
Source: ChEMBL
Target: Cyclin-dependent kinase 6
External Id: CHEMBL3430799
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Name: Antiinvasive activity against human MDA-MB-231 cells assessed as F-actin reorganizati...
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL2089628
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Name: Delta TM value showing the stabilisation of CDKL1 produced by compound binding
Source: ChEMBL
Target: Cyclin-dependent kinase-like 1
External Id: CHEMBL3430800
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| wedelolactone |
| 1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one |
| 1,8,9-trihydroxy-3-methoxycoumestan |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of wedelolactone? |
| A: LogP of wedelolactone is 2.75. |
| Q: What is the melting point of wedelolactone? |
| A: Melting point of wedelolactone is 315 °C. |
| Q: What is the polar surface area (PSA) of wedelolactone? |
| A: Polar surface area (PSA) of wedelolactone is 113.27000. |
| Q: What is the English name of wedelolactone? |
| A: The English name of wedelolactone is wedelolactone. |
| Q: What are the uses of wedelolactone? |
| A: Main uses of wedelolactone: Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3]. |
| Q: What is the boiling point of wedelolactone? |
| A: Boiling point of wedelolactone is 498.4±45.0 °C at 760 mmHg. |
| Q: What is the CAS number of wedelolactone? |
| A: CAS number of wedelolactone is 524-12-9. |
| Q: How is the water solubility of wedelolactone? |
| A: Water solubility of wedelolactone: DMSO: 14 mg/mL, soluble. |
| Q: What are the storage conditions for wedelolactone? |
| A: Storage conditions for wedelolactone: 2-8°C. |
| Q: What are the upstream materials of wedelolactone? |
| A: Related upstream materials(CAS) of wedelolactone: 627489-05-8;1023744-97-9;5447-02-9;27688-86-4;27688-85-3;139-85-5;627489-10-5;627489-15-0;344303-12-4. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |