4-Methylpyrazole hydrochloride
4-Methylpyrazole hydrochloride structure
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Common Name | 4-Methylpyrazole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 56010-88-9 | Molecular Weight | 118.56500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H7ClN2 | Melting Point | 157-159 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 4-Methylpyrazole hydrochlorideFomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. |
Summary: 4-Methylpyrazole hydrochloride (CAS number: 56010-88-9), molecular formula C4H7ClN2, molecular weight 118.56500, For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4-Methylpyrazole hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CYP2E1 |
| In Vivo | Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4] Animal Model: Male CD-1 mice weighing 18-25 g[4] Dosage: 25 mg/kg Administration: IP; single dose Result: Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50). |
| References |
[1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 157-159 °C |
|---|---|
| Molecular Formula | C4H7ClN2 |
| Molecular Weight | 118.56500 |
| Exact Mass | 118.03000 |
| PSA | 28.68000 |
| LogP | 1.52010 |
| InChIKey | PUCXJHNDMYZOHG-UHFFFAOYSA-N |
| SMILES | Cc1cn[nH]c1.Cl |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933199090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933199090 |
|---|---|
| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features.
Clin. Toxicol. (Phila.) 52(10) , 1013-24, (2014) Methanol poisonings occur frequently globally, but reports of larger outbreaks where complete clinical and laboratory data are reported remain scarce. The objective of the present study was to report ... |
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Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus.
Neurosci. Lett. 537 , 40-3, (2013) Consistent with the ability of severe alcohol intoxication to impair memory, high concentrations of ethanol (60mM) acutely inhibit long-term potentiation (LTP) in the CA1 region of rat hippocampal sli... |
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Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.
Eur. J. Pediatr. 174(4) , 509-18, (2015) This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Fomepizole Hydrochloride |
| MFCD00012707 |
| 4-methyl-1H-pyrazole,hydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of 4-Methylpyrazole hydrochloride? |
| A: LogP of 4-Methylpyrazole hydrochloride is 1.52010. |
| Q: What is the molecular formula of 4-Methylpyrazole hydrochloride? |
| A: Molecular formula of 4-Methylpyrazole hydrochloride is C4H7ClN2. |
| Q: What are the uses of 4-Methylpyrazole hydrochloride? |
| A: Main uses of 4-Methylpyrazole hydrochloride: Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. |
| Q: What is the SMILES notation of 4-Methylpyrazole hydrochloride? |
| A: SMILES notation of 4-Methylpyrazole hydrochloride is Cc1cn[nH]c1.Cl. |
| Q: What is the polar surface area (PSA) of 4-Methylpyrazole hydrochloride? |
| A: Polar surface area (PSA) of 4-Methylpyrazole hydrochloride is 28.68000. |
| Q: What is the InChIKey of 4-Methylpyrazole hydrochloride? |
| A: InChIKey of 4-Methylpyrazole hydrochloride is PUCXJHNDMYZOHG-UHFFFAOYSA-N. |
| Q: What is the English name of 4-Methylpyrazole hydrochloride? |
| A: The English name of 4-Methylpyrazole hydrochloride is 4-Methylpyrazole hydrochloride. |
| Q: What is the melting point of 4-Methylpyrazole hydrochloride? |
| A: Melting point of 4-Methylpyrazole hydrochloride is 157-159 °C. |
| Q: What is the safety information for 4-Methylpyrazole hydrochloride? |
| A: Safety information for 4-Methylpyrazole hydrochloride: 26-36. |
| Q: What is the molecular weight of 4-Methylpyrazole hydrochloride? |
| A: Molecular weight of 4-Methylpyrazole hydrochloride is 118.56500. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |