Cefoperazone
Cefoperazone structure
|
Common Name | Cefoperazone | ||
|---|---|---|---|---|
| CAS Number | 62893-19-0 | Molecular Weight | 645.667 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C25H27N9O8S2 | Melting Point | 169-171ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of CefoperazoneCefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.Target: AntibacterialCefoperazone is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins. |
Summary: Cefoperazone, also known as 头孢哌酮, CAS号62893-19-0, molecular formula C25H27N9O8S2, molecular weight 645.667. White crystalline powder, melting point 169-171ºC, density 1.8±0.1 g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | cefoperazone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.Target: AntibacterialCefoperazone is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Melting Point | 169-171ºC |
| Molecular Formula | C25H27N9O8S2 |
| Molecular Weight | 645.667 |
| Exact Mass | 645.142395 |
| PSA | 270.86000 |
| LogP | 1.43 |
| Index of Refraction | 1.819 |
| InChIKey | GCFBRXLSHGKWDP-XCGNWRKASA-N |
| SMILES | CCN1CCN(C(=O)NC(C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CSC23)c2ccc(O)cc2)C(=O)C1=O |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:62893-20-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2941905600 |
|---|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| CEFOPERAZONE ACID |
| Cefoperazone |
| acide (6R,7R)-7-{[(2R)-2-{[(4-éthyl-2,3-dioxopipérazin-1-yl)carbonyl]amino}-2-(4-hydroxyphényl)acétyl]amino}-3-{[(1-méthyl-1H-tétrazol-5-yl)sulfanyl]méthyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ène-2 |
| (6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate |
| Cefobis |
| EINECS 263-749-4 |
| Cefoperazone dihydrate |
| Prestwick_735 |
| HMS1569A15 |
| (6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| HMS2096A15 |
| Cefob |
| CP 52640-2 |
| l~rdum |
| CEFOBID |
| Cephaperazon |
| Medocef |
| 7-[D-(-)-a-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic Acid |
| MFCD00865067 |
| (6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| (6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbon |
| cefoperazine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of cefoperazone? |
| A: LogP of cefoperazone is 1.43. |
| Q: What is the SMILES notation of cefoperazone? |
| A: SMILES notation of cefoperazone is CCN1CCN(C(=O)NC(C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CSC23)c2ccc(O)cc2)C(=O)C1=O. |
| Q: What is the CAS number of cefoperazone? |
| A: CAS number of cefoperazone is 62893-19-0. |
| Q: What is the molecular formula of cefoperazone? |
| A: Molecular formula of cefoperazone is C25H27N9O8S2. |
| Q: What is the English name of cefoperazone? |
| A: The English name of cefoperazone is cefoperazone. |
| Q: What is the InChIKey of cefoperazone? |
| A: InChIKey of cefoperazone is GCFBRXLSHGKWDP-XCGNWRKASA-N. |
| Q: What is the melting point of cefoperazone? |
| A: Melting point of cefoperazone is 169-171ºC. |
| Q: What is the polar surface area (PSA) of cefoperazone? |
| A: Polar surface area (PSA) of cefoperazone is 270.86000. |
| Q: What is the safety information for cefoperazone? |
| A: Safety information for cefoperazone: S26-S36. |
| Q: What is the molecular weight of cefoperazone? |
| A: Molecular weight of cefoperazone is 645.667. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |