Imipenem
Imipenem structure
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Common Name | Imipenem | ||
|---|---|---|---|---|
| CAS Number | 74431-23-5 | Molecular Weight | 317.36 | |
| Density | 1.02 g/mL at 25 °C | Boiling Point | 34.6°C | |
| Molecular Formula | C12H19N3O5S | Melting Point | -116.3°C | |
| MSDS | USA | Flash Point | <−30 °F | |
Use of ImipenemImipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | imipenem hydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3]. |
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| Related Catalog | |
| References |
[2]. Jacoby GA, et al. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.02 g/mL at 25 °C |
|---|---|
| Boiling Point | 34.6°C |
| Melting Point | -116.3°C |
| Molecular Formula | C12H19N3O5S |
| Molecular Weight | 317.36 |
| Flash Point | <−30 °F |
| Exact Mass | 317.104553 |
| PSA | 148.25000 |
| LogP | 0.18820 |
| InChIKey | GSOSVVULSKVSLQ-JJVRHELESA-N |
| SMILES | CC(O)C1C(=O)N2C(C(=O)O)=C(SCCN=CN)CC12.O |
| Storage condition | -20°C Freezer |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F+,C,F |
| Risk Phrases | R12:Extremely Flammable. R14/15:Reacts violently with water, liberating extremely flammable gases . R19:May form explosive peroxides. R22:Harmful if swallowed. R34:Causes burns. R66:Repeated exposure may cause skin dryness or cracking. R67:Vapors may cause |
| Safety Phrases | S16-S26-S36/37/39-S43-S45-S7/8-S27 |
| RIDADR | UN 3399 4.3/PG 1 |
| WGK Germany | 1 |
| Packaging Group | I |
| Hazard Class | 4.3 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Combined disc methods for the detection of KPC- and/or VIM-positive Klebsiella pneumoniae: improving reliability for the double carbapenemase producers.
Clin. Microbiol. Infect. 19(9) , E412-5, (2013) Klebsiella pneumoniae strains co-producing klebsiella pneumoniae carbapenemase (KPC) and verona integron-encoded metallo-beta-lactamase (VIM) are frequently isolated in Greece and have also occurred i... |
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from ... |
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Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.
J. Antimicrob. Chemother. 70 , 1434-42, (2015) Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antibacterial activity against Enterococcus faecalis 850
Source: ChEMBL
Target: Enterococcus faecalis
External Id: CHEMBL679633
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Name: Clearance of compound after iv administration of 20 mg/kg dose in rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL623695
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Name: In vitro antibacterial activity against Escherichia coli 1850
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL679381
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Name: In vitro antibacterial activity against Escherichia coli 1919
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL679383
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Name: In vitro antibacterial activity against Escherichia coli 1850.
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL679385
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Name: In vitro antibacterial activity against staphylococcus aureus smith
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL841568
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Name: In vitro antibacterial activity against streptococcus pneumoniae 6301
Source: ChEMBL
Target: Streptococcus pneumoniae
External Id: CHEMBL840723
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Name: Antibacterial activity against Clostridium perfringens 615E
Source: ChEMBL
Target: Clostridium perfringens
External Id: CHEMBL858493
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Name: Antibacterial activity against permeable mutant Pseudomonas aeruginosa 2033E
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL770317
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Name: In vitro antibacterial activity against Staphylococcus aureus 753 (constitutive beta-...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL801154
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, hydrate (1:1) |
| (5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid monohydrate |
| (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäurehydrat |
| (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1) |
| Imipenem hydrate |
| N-Formimidoylthienamycin Monohydrate |
| MFCD08458212 |
| Imipenem monohydrate |
| Imipenem, Monohydrate |
| EINECS 264-734-5 |
| 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, monohydrate |
| acide (5R,6S)-6-[(1R)-1-hydroxyéthyl]-3-({2-[(iminométhyl)amino]éthyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ène-2-carboxylique hydrate |
| [5R-[5a,6a(R*)]]-6-(1-Hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Monohydrate |
| (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate |
| Imipenem |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of imipenem hydrate? |
| A: InChIKey of imipenem hydrate is GSOSVVULSKVSLQ-JJVRHELESA-N. |
| Q: What is the molecular formula of imipenem hydrate? |
| A: Molecular formula of imipenem hydrate is C12H19N3O5S. |
| Q: What is the molecular weight of imipenem hydrate? |
| A: Molecular weight of imipenem hydrate is 317.36. |
| Q: What is the CAS number of imipenem hydrate? |
| A: CAS number of imipenem hydrate is 74431-23-5. |
| Q: What is the melting point of imipenem hydrate? |
| A: Melting point of imipenem hydrate is -116.3°C. |
| Q: What is the polar surface area (PSA) of imipenem hydrate? |
| A: Polar surface area (PSA) of imipenem hydrate is 148.25000. |
| Q: What are the storage conditions for imipenem hydrate? |
| A: Storage conditions for imipenem hydrate: -20°C Freezer. |
| Q: What is the LogP of imipenem hydrate? |
| A: LogP of imipenem hydrate is 0.18820. |
| Q: What is the SMILES notation of imipenem hydrate? |
| A: SMILES notation of imipenem hydrate is CC(O)C1C(=O)N2C(C(=O)O)=C(SCCN=CN)CC12.O. |
| Q: What are the uses of imipenem hydrate? |
| A: Main uses of imipenem hydrate: Imipenem monohydrate, a member of the carbapenem class of antibiotics isolated from the soil organism Streptomyces cattleya[1], is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including several multi-drug resistant bacterial species. Imipenem acts as cell wall-targeting antibiotic[2][3]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |