Idazoxan Hydrochloride
Idazoxan Hydrochloride structure
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Common Name | Idazoxan Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 79944-56-2 | Molecular Weight | 240.68600 | |
| Density | N/A | Boiling Point | 397ºC at 760 mmHg | |
| Molecular Formula | C11H13ClN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 193.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Idazoxan HydrochlorideIdazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. |
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| Related Catalog | |
| Target |
α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2] |
| In Vivo | Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1]. Animal Model: Male CD-COBS rats injected with 1 mg/kg haloperidol[1] Dosage: 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg Administration: Subcutaneous injection; for 1 hour Result: Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 397ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H13ClN2O2 |
| Molecular Weight | 240.68600 |
| Flash Point | 193.9ºC |
| Exact Mass | 240.06700 |
| PSA | 42.85000 |
| LogP | 1.39450 |
| InChIKey | MYUBYOVCLMEAOH-UHFFFAOYSA-N |
| SMILES | Cl.c1ccc2c(c1)OCC(C1=NCCN1)O2 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 22 |
| Safety Phrases | 7 |
| RIDADR | UN 2811 6.1/PG 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~81%
Idazoxan Hydroc... CAS#:79944-56-2 |
| Literature: Bougaret, Joel; Avan, Jean-Louis; Segonds, Roland Patent: US2005/90537 A1, 2005 ; Location in patent: Page/Page column 8; 9 ; |
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Idazoxan Hydroc... CAS#:79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
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Idazoxan Hydroc... CAS#:79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
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~%
Idazoxan Hydroc... CAS#:79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
![2,3-DIHYDROBENZO[B][1,4]DIOXINE-2-CARBONITRILE structure](https://image.chemsrc.com/caspic/398/1008-92-0.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.
J. Neurosci. 34(22) , 7645-56, (2014) Metabotropic transmission typically occurs through the spillover activation of extrasynaptic receptors. This study examined the mechanisms underlying somatodendritic dopamine and noradrenaline transmi... |
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Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.
Br. J. Pharmacol. 173 , 415-28, (2016) This article is commented on by Michel, M. C., pp. 429-430 of this issue. To view this commentary visit http://dx.doi.org/10.1111/bph.13379.Mirabegron is the first β3 -adrenoceptor agonist approved fo... |
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Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors
Brain Res. Bull. 86(5-6) , 412-21, (2011) Highlights ► DBV's anti-nociceptive effect involves suppression of spinal astrocyte activation. ► DBV-induced astrocyte inhibition is mediated by spinal alpha-2A and alpha-2C adrenoceptors. ► Astrocyt... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Idazoxan Hydrochloride |
| Melanotan II |
| IdazoxanHCl |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: Polar surface area (PSA) of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is 42.85000. |
| Q: What is the molecular formula of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: Molecular formula of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is C11H13ClN2O2. |
| Q: What are the upstream materials of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: Related upstream materials(CAS) of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride: 1008-92-0;107-15-3;120-80-9;79944-55-1. |
| Q: What is the molecular weight of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: Molecular weight of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is 240.68600. |
| Q: What is the CAS number of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: CAS number of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is 79944-56-2. |
| Q: What is the English name of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: The English name of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride. |
| Q: What is the LogP of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: LogP of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is 1.39450. |
| Q: What English synonyms does Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride have? |
| A: English synonyms of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride: Idazoxan Hydrochloride, Melanotan II, IdazoxanHCl. |
| Q: What is the InChIKey of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: InChIKey of Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride is MYUBYOVCLMEAOH-UHFFFAOYSA-N. |
| Q: What is the safety information for Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride? |
| A: Safety information for Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride: 7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |