79944-56-2
79944-56-2 structure
- Name: Idazoxan Hydrochloride
- Chemical Name: Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
- CAS Number: 79944-56-2
- Molecular Formula: C11H13ClN2O2
- Molecular Weight: 240.68600
- Catalog: Research Areas Endocrinology
- Create Date: 2017-01-01 20:16:51
- Modify Date: 2025-08-21 19:10:16
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Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2].
| Name | Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride |
|---|---|
| Synonyms |
Idazoxan Hydrochloride
Melanotan II IdazoxanHCl |
| Description | Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2]. |
|---|---|
| Related Catalog | |
| Target |
α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2] |
| In Vivo | Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1]. Animal Model: Male CD-COBS rats injected with 1 mg/kg haloperidol[1] Dosage: 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg Administration: Subcutaneous injection; for 1 hour Result: Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. |
| References |
| Boiling Point | 397ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H13ClN2O2 |
| Molecular Weight | 240.68600 |
| Flash Point | 193.9ºC |
| Exact Mass | 240.06700 |
| PSA | 42.85000 |
| LogP | 1.39450 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 22 |
| Safety Phrases | 7 |
| RIDADR | UN 2811 6.1/PG 3 |
|
~81%
79944-56-2 |
| Literature: Bougaret, Joel; Avan, Jean-Louis; Segonds, Roland Patent: US2005/90537 A1, 2005 ; Location in patent: Page/Page column 8; 9 ; |
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79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
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79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
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79944-56-2 |
| Literature: Tetrahedron Letters, , vol. 22, # 48 p. 4839 - 4842 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |