Solasodine
Modify Date: 2026-07-03 11:54:05
Solasodine structure
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Common Name | Solasodine | ||
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| CAS Number | 126-17-0 | Molecular Weight | 413.636 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 537.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C27H43NO2 | Melting Point | 284 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 279.1±30.1 °C | |
Use of SolasodineSolasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937).IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1]Target: Anticancerin vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2].in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Solasodine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937).IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1]Target: Anticancerin vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2].in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 537.9±50.0 °C at 760 mmHg |
| Melting Point | 284 °C (dec.)(lit.) |
| Molecular Formula | C27H43NO2 |
| Molecular Weight | 413.636 |
| Flash Point | 279.1±30.1 °C |
| Exact Mass | 413.329376 |
| PSA | 41.49000 |
| LogP | 5.78 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.572 |
| InChIKey | KWVISVAMQJWJSZ-VKROHFNGSA-N |
| SMILES | CC1CCC2(NC1)OC1CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C2C |
| Storage condition | 2-8°C |
| Water Solubility | 200 g/L (25 ºC) |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Safety Phrases | S22-S24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | WF1300000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
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| DownStream 3 | |
CAS#:6785-55-3
CAS#:19121-58-5
CAS#:6106-33-8
CAS#:114696-99-0
CAS#:115388-90-4
CAS#:468-99-5
CAS#:54302-48-6
CAS#:129850-55-1
CAS#:979-02-2
CAS#:55320-51-9
CAS#:17094-86-9This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: qHTS of TDP-43 Inhibitors: NCGC Sytravon Library Screen
Source: NCGC
External Id: tdp43-p2-repeat
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule modulators of NR3A
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: SBCCG-A1015-NR3A-Primary-Assay
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (3b,22a,25R)-Spirosol-5-en-3-ol |
| Solanearpidine |
| Solasod-5-en-3β-ol |
| (3β,22α,25R)-Spirosol-5-en-3-ol |
| Solancarpidine |
| Solasod-5-en-3b-ol |
| Solasod-5-en-3β-ol (8CI) |
| Purapuridine |
| MFCD00037844 |
| EINECS 204-774-2 |
| Solasod-5-en-3-β-ol |
| Solanidine-S |
| Solasodine |
| D5-20bF,22aF,25aF,28-azaspirosten-3b-ol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of Solasodine? |
| A: Related upstream materials(CAS) of Solasodine: 6785-55-3;19121-58-5;6106-33-8;114696-99-0;115388-90-4;468-99-5;54302-48-6;129850-55-1. |
| Q: What is the molecular weight of Solasodine? |
| A: Molecular weight of Solasodine is 413.636. |
| Q: What is the melting point of Solasodine? |
| A: Melting point of Solasodine is 284 °C (dec.)(lit.). |
| Q: What is the polar surface area (PSA) of Solasodine? |
| A: Polar surface area (PSA) of Solasodine is 41.49000. |
| Q: What is the LogP of Solasodine? |
| A: LogP of Solasodine is 5.78. |
| Q: What is the English name of Solasodine? |
| A: The English name of Solasodine is Solasodine. |
| Q: What is the InChIKey of Solasodine? |
| A: InChIKey of Solasodine is KWVISVAMQJWJSZ-VKROHFNGSA-N. |
| Q: What are the storage conditions for Solasodine? |
| A: Storage conditions for Solasodine: 2-8°C. |
| Q: What is the boiling point of Solasodine? |
| A: Boiling point of Solasodine is 537.9±50.0 °C at 760 mmHg. |
| Q: How is the water solubility of Solasodine? |
| A: Water solubility of Solasodine: 200 g/L (25 ºC). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |