1-Adamantanamine hydrochloride structure
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Common Name | 1-Adamantanamine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 665-66-7 | Molecular Weight | 187.710 | |
| Density | 1.067g/cm3 | Boiling Point | 225.7ºC at 760 mmHg | |
| Molecular Formula | C10H18ClN | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 96ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 1-Adamantanamine hydrochlorideAmantadine Hydrochloride is an antiviral and an antiparkinsonian drug.Target: Influenza VirusAmantadine is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. Amantadine binding of M2, based on studies of a peptide representing the M2 transmembrane segment in dodecylphosphocholine micelles. Amantadine competes with protons for binding to the deprotonated tetramer, thereby stabilizing the tetramer in a slightly altered conformation. This model accounts for the observed inhibition of proton flux by amantadine [1]. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Amantadine binding inhibits current flow through NMDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentrations results from stabilization of closed states of the channel [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | amantadine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.Target: Influenza VirusAmantadine is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. Amantadine binding of M2, based on studies of a peptide representing the M2 transmembrane segment in dodecylphosphocholine micelles. Amantadine competes with protons for binding to the deprotonated tetramer, thereby stabilizing the tetramer in a slightly altered conformation. This model accounts for the observed inhibition of proton flux by amantadine [1]. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Amantadine binding inhibits current flow through NMDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentrations results from stabilization of closed states of the channel [2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.067g/cm3 |
|---|---|
| Boiling Point | 225.7ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C10H18ClN |
| Molecular Weight | 187.710 |
| Flash Point | 96ºC |
| Exact Mass | 187.112778 |
| PSA | 26.02000 |
| LogP | 3.41620 |
| Index of Refraction | 1.558 |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
| SMILES | Cl.NC12CC3CC(CC(C3)C1)C2 |
| Water Solubility | soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S22-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU4375000 |
| HS Code | 2921300090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~97%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: Hays, David S.; Fu, Gregory C. Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2796 - 2797 |
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~82%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: Tsutsui, Hironori; Ichikawa, Tomoko; Narasaka, Koichi Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1869 - 1878 |
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~%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: Organic Letters, , vol. 11, # 2 p. 433 - 436 |
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~%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: WO2007/96124 A1, ; Page/Page column 15-16 ; |
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~10%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: Huard, Kim; Lebel, Helene Chemistry - A European Journal, 2008 , vol. 14, # 20 p. 6222 - 6230 |
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~%
1-Adamantanamin... CAS#:665-66-7 |
| Literature: Journal of Organic Chemistry, , vol. 45, # 26 p. 5239 - 5243 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 10 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2921300090 |
|---|---|
| Summary | 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes.
Colloids Surf. B Biointerfaces 105 , 31-6, (2013) This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped... |
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In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib.
J. Hematol. Oncol. 8 , 81, (2015) Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clin... |
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Platinum-Incorporating Poly(N-vinylpyrrolidone)-poly(aspartic acid) Pseudoblock Copolymer Nanoparticles for Drug Delivery.
Biomacromolecules 16 , 2059-71, (2015) Cisplatin-incorporating pseudoblock copolymer nanoparticles with high drug loading efficiency (ca. 50%) were prepared built on host-guest inclusion complexation between β-cyclodextrin end-capped poly(... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
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Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
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Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185
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Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Amazolon |
| adamantanamine hydrochloride |
| Amantadine HCl |
| Lysovir |
| EINECS 211-560-2 |
| MFCD00074723 |
| virasol |
| 1-aminoadamantane hydrochloride |
| Virofral |
| 1-Adamantanaminehydrochloride |
| Mantadix |
| 1-adamantamine hydrochloride |
| Midantan |
| 1-Adamantanamine hydrochloride |
| Adekin |
| Mantadan |
| 1-adamantylamine hydrochloride |
| exp105-1 |
| Amantadine hydrochloride |
| Amantadine (hydrochloride) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of amantadine hydrochloride? |
| A: Related downstream products(CAS) of amantadine hydrochloride: 3717-60-0;4411-25-0;5689-59-8;22110-53-8;458529-20-9;2387-23-7;274901-16-5;702-82-9;768-94-5;13072-69-0. |
| Q: How is the water solubility of amantadine hydrochloride? |
| A: Water solubility of amantadine hydrochloride: soluble. |
| Q: What is the LogP of amantadine hydrochloride? |
| A: LogP of amantadine hydrochloride is 3.41620. |
| Q: What is the English name of amantadine hydrochloride? |
| A: The English name of amantadine hydrochloride is amantadine hydrochloride. |
| Q: What is the molecular weight of amantadine hydrochloride? |
| A: Molecular weight of amantadine hydrochloride is 187.710. |
| Q: What is the CAS number of amantadine hydrochloride? |
| A: CAS number of amantadine hydrochloride is 665-66-7. |
| Q: What are the upstream materials of amantadine hydrochloride? |
| A: Related upstream materials(CAS) of amantadine hydrochloride: 24886-73-5;57680-77-0;880-52-4;768-94-5;24375-06-2. |
| Q: What is the melting point of amantadine hydrochloride? |
| A: Melting point of amantadine hydrochloride is >300 °C(lit.). |
| Q: What English synonyms does amantadine hydrochloride have? |
| A: English synonyms of amantadine hydrochloride: Amazolon, adamantanamine hydrochloride, Amantadine HCl, Lysovir, EINECS 211-560-2, MFCD00074723, virasol, 1-aminoadamantane hydrochloride, Virofral, 1-Adamantanaminehydrochloride, Mantadix, 1-adamantamine hydrochloride, Midantan, 1-Adamantanamine hydrochloride, Adekin, Mantadan, 1-adamantylamine hydrochloride, exp105-1, Amantadine hydrochloride, Amantadine (hydrochloride). |
| Q: What is the SMILES notation of amantadine hydrochloride? |
| A: SMILES notation of amantadine hydrochloride is Cl.NC12CC3CC(CC(C3)C1)C2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |
| Zhongshan Xingrui Chemical Co. , Ltd. |