Adamantan-1-amine

Modify Date: 2024-01-02 12:58:06

Adamantan-1-amine structure	Common Name	Adamantan-1-amine
	CAS Number	768-94-5	Molecular Weight	151.249
	Density	1.1±0.1 g/cm3	Boiling Point	225.7±8.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₇N	Melting Point	206-208 °C(lit.)
	MSDS	Chinese USA	Flash Point	96.0±9.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Adamantan-1-amine

Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

Name	amantadine
Synonym	More Synonyms

Description	Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
References	[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

References

[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.

[2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

Density	1.1±0.1 g/cm3
Boiling Point	225.7±8.0 °C at 760 mmHg
Melting Point	206-208 °C(lit.)
Molecular Formula	C₁₀H₁₇N
Molecular Weight	151.249
Flash Point	96.0±9.7 °C
Exact Mass	151.136093
PSA	26.02000
LogP	2.22
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.558

Adamantan-1-amine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD1925000

CHEMICAL NAME :: Tricyclo(3.3.1.1(sup 3,7))decan-1-amine

CAS REGISTRY NUMBER :: 768-94-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H17-N

MOLECULAR WEIGHT :: 151.28

WISWESSER LINE NOTATION :: L66 B6 A B- C 1B ITJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YD1925000

Precursor 8
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DownStream 10
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1-Adamantanamine

EXP 105-1

1-Amantadine

(3s,5s,7s)-adamantan-1-amine

adamantan-1-amine

tricyclo[3.3.1.13,7]decan-1-amine

Symmetrel

TCMDC-125869

Tricyclo[3.3.1.1]decan-1-amine

SYMADINE

1-Adamantylamine

Mydantane

(3s,5s,7s)-1-Adamantanamine

adamantylamine

EINECS 212-201-2

Amantadine

1-Aminotricyclo[3.3.1.13,7]decane

Adamantanamine

1-aminoadamantine

adamantyl amine

tricyclo[3.3.1.1]décan-1-amine

Trivaline

Pk-merz

Amazolon

1-Aminodiamantane

1-adamantaneamine

1-aminoadamantane

MFCD00074732

Aminoadamantane

Mantadine

Tricyclo[3.3.1.1^3,7]decan-1-amine

Virofral

1-aminoadamantan

Tricyclo[3.3.1.1]decan-1-amin

Virasol

Amantadine Base

Influenol

1-Adamantanamine (8CI)

Adamantamine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Adamantan-1-amine
Price: ￥188.0/25g ￥568.0/100g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: ADS-5102
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Aminoadamantane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: amantadine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Adamantan-1-amine

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