Palladium-catalyzed double carbonylation of aryl halides to give. alpha.-keto amides. Mechanistic studies

…, H Soyama, H Yanagihara, I Aoyama…

Index: Ozawa, Fumiyuki; Soyama, Hidehiko; Yanagihara, Hisayoshi; Aoyama, Issei; Takino, Hiroaki; et al. Journal of the American Chemical Society, 1985 , vol. 107, # 11 p. 3235 - 3245

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Citation Number: 170

Abstract

Abstract: Various aryl halides are catalytically converted into a-keto amides and amides on treatment with secondary amines and carbon monoxide. Palladium complexes containing tertiary phosphine ligands, particularly diphenylmethylphosphine and 1, 4-bis (diphenylphosphino) butane, are most effective among other transition-metal complexes. Detailed examination of factors controlling the reaction rates and selectivity for a-keto ...