Journal of Peptide Science 2001-03-01

Properties and applications of the (2-nitrofluoren-9-yl)methoxycarbonyl group.

B Henkel, E Bayer

Index: J. Pept. Sci. 7(3) , 152-6, (2001)

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Abstract

This paper presents a new protecting group, the (2-nitrofluoren-9-yl)methoxycarbonyl group. Investigations on the properties of this new modification of the Fmoc-system, such as the solvent-dependent photochemical cleavage, and enhanced lability towards bases, are described, as well as UV-kinetic measurements of the cleavage reaction. In addition, the incorporation of the (2-nitrofluoren-9-yl)methoxycarbonyl group into two peptides, and a sequence-dependent photochemical cleavage reaction are reported.