Life Sciences 2013-01-01

Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line

Shigeo Akiyama, Takayuki Ogiwara, Tomoyuki Aoki, Katsuhiko Tsunekawa, Osamu Araki, Masami Murakami

Index: Life Sci. 115(1-2) , 22-8, (2014)

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Abstract

Aims The pathophysiological roles of thyroid hormones in glucose metabolism remain uncertain. Type 3 iodothyronine deiodinase (D3) converts thyroxine (T4) and 3,5,3′-triiodothyronine (T3) to 3,3′,5′-triiodothyronine (rT3) and 3,3′-diiodothyronine (T2), respectively, inactivating thyroid hormones in a cell-specific fashion. In the present study, we identified D3 expression in MIN6 cells derived from a mouse insulinoma cell line and examined the mechanisms regulating D3 expression in these cells.