3,3',5'-triiodothyronine

Modify Date: 2025-08-21 11:40:41

3,3',5'-triiodothyronine Structure
3,3',5'-triiodothyronine structure
 Common Name 3,3',5'-triiodothyronine
CAS Number 5817-39-0 Molecular Weight 650.974
Density 2.4±0.1 g/cm3 Boiling Point 534.6±50.0 °C at 760 mmHg
Molecular Formula C15H12I3NO4 Melting Point 234-238ºC(lit.)
MSDS Chinese USA Flash Point 277.1±30.1 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Use of 3,3',5'-triiodothyronine


Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].

 Names

Name 3,3',5'-triiodothyronine
Synonym More Synonyms

 3,3',5'-triiodothyronine Biological Activity

Description Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].
Related Catalog
References

[1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9.

[2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749.

 Chemical & Physical Properties

Density 2.4±0.1 g/cm3
Boiling Point 534.6±50.0 °C at 760 mmHg
Melting Point 234-238ºC(lit.)
Molecular Formula C15H12I3NO4
Molecular Weight 650.974
Flash Point 277.1±30.1 °C
Exact Mass 650.790039
PSA 92.78000
LogP 5.39
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.763
Storage condition 2-8°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R36/37/38
Safety Phrases 36
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS AY6750000
HS Code 2922509090

 Synthetic Route

L-thyroxine structure

L-thyroxine

CAS#:51-48-9

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: European Journal of Clinical Pharmacology, , vol. 55, # 11-12 p. 807 - 814
3-iodo-l-thyronine structure

3-iodo-l-thyronine

CAS#:10468-90-3

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069
(2S)-2-acetamido-3-(4-hydroxy-3-iodophenyl)propanoic acid structure

(2S)-2-acetamid...

CAS#:1023-47-8

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069
N-ACETYL-3-IODO-4-(4-METHOXYPHENOXY)-L-PHENYLALANINE AMIDE structure

N-ACETYL-3-IODO...

CAS#:59302-20-4

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069
N-Acetyl-3-iodo-L-tyrosine, Amide structure

N-Acetyl-3-iodo...

CAS#:59302-19-1

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069
N/A structure

N/A

CAS#:903571-91-5

L-thyroxine structure

L-thyroxine

CAS#:51-48-9

~%

Naphtho[1,8-cd]-1,2-thiaselenole structure

Naphtho[1,8-cd]...

CAS#:64869-35-8

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249
7-((ethylamino)methyl)-8-hydroselenonaphthalene-1-thiol structure

7-((ethylamino)...

CAS#:1261500-99-5

L-thyroxine structure

L-thyroxine

CAS#:51-48-9

~%

N/A structure

N/A

CAS#:1261501-03-4

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249
L-thyroxine structure

L-thyroxine

CAS#:51-48-9

1,8-Naphthalenedithiol structure

1,8-Naphthalene...

CAS#:25079-77-0

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

1,8-Epidithionaphthalene structure

1,8-Epidithiona...

CAS#:209-22-3

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]propanoic acid structure

(2S)-2-amino-3-...

CAS#:4192-14-7

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Zeitschrift fuer Physikalische Chemie (Leipzig), , vol. 271, # 1 p. 223 - 226

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles34

More Articles
Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood.

J. Endocrinol. 226 , 219-26, (2015)

Early overnutrition (EO) during lactation leads to obesity, leptin resistance and lower thyroid hormone (TH) levels during adulthood. To better understand the biological significance of this thyroid h...

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men.

Eur. J. Endocrinol. 169(6) , 835-44, (2013)

Variation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have ...

Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver.

Toxicol. Sci. 124(2) , 339-47, (2011)

Halogenated contaminants, particularly brominated flame retardants, disrupt circulating levels of thyroid hormones (THs), potentially affecting growth and development. Disruption may be mediated by im...

 Synonyms

(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid
3,3',5'-Triiodo-L-thyronine
Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-
Reverse triiodothyronine
REVERSE T3
O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine
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