Biochemical and Biophysical Research Communications 2011-06-17

Structure–function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells

Emanuel Berger, Dirk Haller

Index: Biochem. Biophys. Res. Commun. 409 , 610, (2011)

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Abstract

Highlights ► TUDCA inhibits the expression of ER stress markers in intestinal epithelial cells. ► TUDCA prohibits the activation of the unfolded protein response in these cells. ► UDCA but not taurine mediates the inhibitory effects of TUDCA. ► The hydrophobic parts of TUDCA prohibit the aggregation of denatured proteins.