Chemical Communications 2014-10-18

Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation.

Q Yu, E M Rodriguez, R Naccache, P Forgione, G Lamoureux, F Sanz-Rodriguez, D Scheglmann, J A Capobianco

Index: Chem. Commun. (Camb.) 50(81) , 12150-3, (2014)

Full Text: HTML

Abstract

LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.