Modular synthesis of indoles from imines and o-Dihaloarenes or o-Chlorosulfonates by a Pd-catalyzed cascade process

J Barluenga, A Jimenez-Aquino, F Aznar…

Index: Barluenga, Jose; Jimenez-Aquino, Agustin; Aznar, Fernando; Valdes, Carlos Journal of the American Chemical Society, 2009 , vol. 131, p. 4031 - 4041

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Citation Number: 133

Abstract

A detailed study of the scope of a new Pd-catalyzed synthesis of indoles from 1, 2- dihaloarenes and o-halobenzene sulfonates and imines is described. The cascade reaction comprises an imine α-arylation followed by an intramolecular C− N bond-forming reaction promoted by the same Pd catalyst. The reaction with 1, 2-dibromobenzene shows wide scope and allows the introduction of aryl, alkyl, and vinyl substituents at different positions ...