RSC Advances

The sequential reactions of tetrazoles with bromoalkynes for the synthesis of (Z)-N-(2-bromo-1-vinyl)-N-arylcyanamides and 2-arylindoles

J Zhang, LG Meng, P Li, L Wang

Index: Zhang, Jiajun; Meng, Ling-Guo; Li, Pinhua; Wang, Lei RSC Advances, 2013 , vol. 3, # 19 p. 6807 - 6812

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Citation Number: 6

Abstract

2-Arylindoles were prepared by a sequential reaction of Ag-catalyzed α-addition–Pd- catalyzed C–H bond functionalization of tetrazoles with bromoalkynes. A stereocontrolled Ag- catalyzed α-addition reaction of tetrazoles with bromoalkynes underwent smoothly to generate (Z)-N-(2-bromo-1-vinyl)-N-arylcyanamides, which were subsequently converted into 2-arylindoles through an intramolecular cyclization by Pd-catalyzed direct C–H bond ...