Tetrahedron

Strategic studies in the syntheses of novel 6, 7-substituted quinolones and 7-or 6-substituted 1, 6-and 1, 7-naphthyridones

…, P Boutron, F Jung, M Lamorlette, M Maudet, P Plé

Index: Morgentin, Remy; Pasquet, Georges; Boutron, Pascal; Jung, Frederic; Lamorlette, Maryannick; Maudet, Mickael; Ple, Patrick Tetrahedron, 2008 , vol. 64, # 12 p. 2772 - 2782

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Citation Number: 13

Abstract

This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6, 7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1, 6- naphthyridin-4-one and 6-substituted-1H-1, 7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks.