Chemical Communications 2012-02-28

Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers.

Xin Huang, Jin Peng, Lin Dong, Ying-Chun Chen

Index: Chem. Commun. (Camb.) 48(18) , 2439-41, (2012)

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Abstract

The first organocatalytic asymmetric assembly of Morita-Baylis-Hillman carbonates of isatins and α-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr >95:5).This journal is © The Royal Society of Chemistry 2012