Archiv der Pharmazie (Weinheim) 2005-12-01

New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.

Sun-Hee Lee, Sun-Kyoung Park, Jeong-Mi Kim, Myung-Hwa Kim, Kwang-Hee Kim, Kwang-Woo Chun, Kyung-Hea Cho, Ji-Youn Youn, Sung Keon Namgoong

Index: Arch. Pharm. (Weinheim) 338(12) , 582-9, (2005)

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Abstract

New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.