International Journal of Pediatric Otorhinolaryngology 2010-01-01

Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC)

Jae-Jun Song, Seong Keun Kwon, Chang Gun Cho, Seok-Won Park, Sung-Won Chae, Jae-Jun Song, Seong Keun Kwon, Chang Gun Cho, Seok-Won Park, Sung-Won Chae

Index: Int. J. Pediatr. Otorhinolaryngol. 74(12) , 1384-7, (2010)

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Abstract

Objective Guggulsterone is a bioactive constituent of resinous sap originating from the guggul tree, Commiphora mukul, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. However, the effect of guggulsterone inflammatory reactions induced by lipopolysaccharide (LSP) is not known. The aim of this study was to evaluate the anti-inflammatory effect of guggulsterone on cultured human middle ear epithelial cells (HMEEC).