Dalton Transactions (Print Edition) 2013-02-14

Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis.

Gregorio Guisado-Barrios, Bianca K Muñoz, Paul C J Kamer, Bas Lastdrager, Gijs van der Marel, Mark Overhand, Marino Vega-Vázquez, Manuel Martin-Pastor

Index: Dalton Trans. 42(6) , 1973-8, (2013)

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Abstract

The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(I) complexes allowed asymmetric hydrogenation with 10-52% ee and the corresponding Pd(II) analogues catalysed asymmetric allylic alkylation with 13-15% ee.