Chemical Biology & Drug Design 2010-03-01

Select acetophenones modulate flagellar motility in chlamydomonas.

Shakila K Evans, Austin A Pearce, Prudence K Ibezim, Todd P Primm, Anne R Gaillard

Index: Chem. Biol. Drug Des. 75 , 333-337, (2010)

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Abstract

Acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires co-ordinated flagellar motility. The structure-activity relationships of a series of acetophenones are reported, including acetophenones that affect flagellar motility and cell viability. Notably, 4-methoxyacetophenone, 3,4-dimethoxyacetophenone, and 4-hydroxyacetophenone induced negative phototaxis in Chlamydomonas, suggesting interference with activity of flagellar proteins and control of flagellar dominance.