Journal of Natural Products 2005-07-01

A labdane diterpene glucoside from the rhizomes of Curcuma mangga.

Faridah Abas, Nordin H Lajis, Khozirah Shaari, Daud Ahmad Israf, Johnson Stanslas, Umi Kalsom Yusuf, Salahuddin Mohd Raof

Index: J. Nat. Prod. 68 , 1090-3, (2005)

Full Text: HTML

Abstract

A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.