Tetrahedron Letters 2011-10-01

Suzuki-Miyaura Cross-Coupling of Benzylic Bromides Under Microwave Conditions.

StevenW McDaniel, CharlesM Keyari, KevinC Rider, NicholasR Natale, Philippe Diaz

Index: Tetrahedron Lett. 52(43) , 5656-5658, (2011)

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Abstract

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.