Asymmetric Cyanoethoxy Carbonylation Reaction of Aldehydes Catalyzed by a TiIV Macrocyclic Complex: An Efficient Synthetic Protocol for β??Blocker and α1?? …

…, NH Khan, RI Kureshy, SHR Abdi, HC Bajaj

Index: Saravanan; Sadhukhan, Arghya; Khan, Noor-Ul H.; Kureshy, Rukhsana I.; Abdi, Sayed H. R.; Bajaj, Hari C. Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4375 - 4384

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Citation Number: 6

Abstract

Abstract Chiral macrocyclic Ti IV–salen complexes were used as efficient catalysts in the asymmetric cyanoethoxy carbonylation of aldehydes. The Ti IV catalysts demonstrated excellent performance (product yields and ee values up to 99%) with ethyl cyanoformate as the cyanide source and a catalyst loading of 0.5 mol%, which is the lowest known. The macrocyclic Ti IV–salen complex retained its performance at multigram level and was ...