Asymmetric Cyanoethoxy Carbonylation Reaction of Aldehydes Catalyzed by a TiIV Macrocyclic Complex: An Efficient Synthetic Protocol for β??Blocker and α1?? …

…, NH Khan, RI Kureshy, SHR Abdi, HC Bajaj

文献索引：Saravanan; Sadhukhan, Arghya; Khan, Noor-Ul H.; Kureshy, Rukhsana I.; Abdi, Sayed H. R.; Bajaj, Hari C. Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4375 - 4384

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被引用次数: 6

摘要

Abstract Chiral macrocyclic Ti IV–salen complexes were used as efficient catalysts in the asymmetric cyanoethoxy carbonylation of aldehydes. The Ti IV catalysts demonstrated excellent performance (product yields and ee values up to 99%) with ethyl cyanoformate as the cyanide source and a catalyst loading of 0.5 mol%, which is the lowest known. The macrocyclic Ti IV–salen complex retained its performance at multigram level and was ...