Journal of the American Chemical Society

Asymmetric synthesis of monosubstituted and. alpha.,. alpha.-disubstituted. alpha.-amino acids via diastereoselective glycine enolate alkylations

RM Williams, MN Im

文献索引：Williams; Im Journal of the American Chemical Society, 1991 , vol. 113, # 24 p. 9276 - 9286

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被引用次数: 241

摘要

Nonproteinogenic, unnatural a-amino acids have increasingly attracted the attention of numerous disciplines in connection with the design and synthesis of enzyme inhibitors as potential constituents of pharmaceuticals, as optically active starting materials for a variety of synthetic applications, and for the study of enzymatic reaction mechanisms. As a consequence, numerous and versatile approaches to the synthesis of nonproteinogenic, ...